ERα degrader 13

Catalog No.: A85224
ERα Degrader
ERα Degrader 13 is a potent degrader of estrogen receptor alpha (ERα) with an IC50 value of 0.55 μM. This compound effectively induces tumor regression in breast cancer xenograft mouse models, making it a valuable tool for studying ERα-related signaling and therapeutic approaches in breast cancer. Its targeted degradation mechanism provides insights into the role of ERα in cancer progression and treatment resistance.
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Size Stock
5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionERα Degrader 13 is a potent degrader of estrogen receptor alpha (ERα) with an IC50 value of 0.55 μM. This compound effectively induces tumor regression in breast cancer xenograft mouse models, making it a valuable tool for studying ERα-related signaling and therapeutic approaches in breast cancer. Its targeted degradation mechanism provides insights into the role of ERα in cancer progression and treatment resistance.
Product Information
Catalog NumA85224
FormulaC50H48N4O5S2
Molecular Weight849.07
CAS Number3070968-56-5
SMILESCCN(C1=CC=C2N=C(C(SC2=C1)=C/C3=N/CCCCCCC(NCCOC4=CC=C(C=C4)C(C5=C(SC6=C5C=CC(O)=C6)C7=CC=C(C=C7)O)=O)=O)C8=C3C=CC=C8)CC
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