Erlotinib-d4 is a deuterium-labeled analog of Erlotinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM and is utilized in the treatment of non-small cell lung cancer. Additionally, Erlotinib-d4 serves as a valuable click chemistry reagent, featuring an alkyne group for performing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications.
Erlotinib-d4 is a deuterium-labeled analog of Erlotinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM and is utilized in the treatment of non-small cell lung cancer. Additionally, Erlotinib-d4 serves as a valuable click chemistry reagent, featuring an alkyne group for performing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications.
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