ERRα antagonist-2 is an inverse agonist of the estrogen-related receptor alpha (ERRα), exhibiting an IC50 of 0.80 μM. This compound effectively inhibits the migration and invasion of the ER-negative MDA-MB-231 breast cancer cell line. Furthermore, ERRα antagonist-2 demonstrates the ability to suppress breast cancer growth in vivo, making it a valuable tool for research into breast cancer therapies and the role of ERRα in cancer progression.
ERRα antagonist-2 is an inverse agonist of the estrogen-related receptor alpha (ERRα), exhibiting an IC50 of 0.80 μM. This compound effectively inhibits the migration and invasion of the ER-negative MDA-MB-231 breast cancer cell line. Furthermore, ERRα antagonist-2 demonstrates the ability to suppress breast cancer growth in vivo, making it a valuable tool for research into breast cancer therapies and the role of ERRα in cancer progression.
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