ES-8891 is a selective renin inhibitor that effectively reduces plasma renin activity and immunoreactive renin concentrations. In a study involving normotensive sodium-depleted macaques, administration of ES-8891 led to a significant decrease in plasma angiotensin I levels and a notable reduction in mean blood pressure, without affecting heart rate. This compound serves as a valuable tool for research on blood pressure regulation and the renin-angiotensin system.
ES-8891 is a selective renin inhibitor that effectively reduces plasma renin activity and immunoreactive renin concentrations. In a study involving normotensive sodium-depleted macaques, administration of ES-8891 led to a significant decrease in plasma angiotensin I levels and a notable reduction in mean blood pressure, without affecting heart rate. This compound serves as a valuable tool for research on blood pressure regulation and the renin-angiotensin system.
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