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Estradiol 3-methyl ether

Name: Estradiol 3-methyl ether
Brand: Adooq Bioscience
SKU: A68759
Availability: InStock

Cat. No. A68759 CAS 1035-77-4

TRPML1 Channel Antagonist/Microtubule Depolymerizer

Estradiol 3-methyl ether (EDME) is a potent antagonist of the TRPML1 ion channel and a microtubule depolymerizer. It exhibits remarkable selectivity, with IC50 values of 0.22 μM against TRPML1 and 3.8 μM against TRPML2, while showing no activity towards TRPML3. EDME disrupts cytoplasmic microtubule networks in mammalian cells with an EC50 of 9 μM. This compound operates independently of estrogen receptors to block autophagy, inhibit TFEB nuclear translocation, and reduce migration and invasion in triple-negative breast cancer cells, making it highly relevant for research in cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1035-77-4
Applications	TRPML1 Channel Antagonist/Microtubule Depolymerizer
Formula	C₁₉H₂₆O₂
Molecular Weight	286.41
Synonyms	3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol
SMILES	C[C@]12CC[C@]3([H])C4=CC=C(OC)C=C4CC[C@@]3([H])[C@]1([H])CC[C@]2([H])O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Estradiol 3-methyl ether

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