TRP Channel

Cat. No.

A12353

CAS No.

1170613-55-4

A 967079

A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively).

Cat. No.

A12727

CAS No.

659730-32-2

AMG517

AMG 517 is a potent and selective TRPV1 antagonist.

Cat. No.

A16103

CAS No.

1209500-46-8

GsMTx4

GsMTX4 is a 34 amino acid peptidyl toxin isolated from the Grammostola rosea (Chilean rose) tarantula venom and belongs to the huwentoxin-1 family.

Cat. No.

A20786

CAS No.

1315323-00-2

Pyr10

Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.

Cat. No.

A13344

CAS No.

1628287-16-0

Pico145

Synonyms: HC-608

Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.

Cat. No.

A20092

CAS No.

1154-25-2

EIPA

Synonyms: L593754; MH 12-43

EIPA (L593754; MH 12-43) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA (L593754; MH 12-43) also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.

Cat. No.

A10376

CAS No.

518-17-2

Evodiamine (Isoevodiamine)

Synonyms: Isoevodiamine

Evodiamine is a chemical extracted from the Tetradium family of plants. It acts primarily as a thermogenic and stimulant.

Cat. No.

A11143

CAS No.

501951-42-4

SB-705498

SB-705498 is a potent, selective and orally bioavailable TRPV1 antagonist.

Cat. No.

A12309

CAS No.

901715-05-7

TRPC6-IN-1

TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM.

Cat. No.

A12766

CAS No.

821768-06-3

JNJ-17203212

NJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.

Cat. No.

A12932

CAS No.

348575-88-2

Optovin

Optovin is a reversible photoactive TRPA1 activator.

Cat. No.

A13278

CAS No.

349085-38-7

HC-030031

HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 uM, respectively).

Cat. No.

A13497

CAS No.

1072921-02-8

A-889425

A-889425 is a selective TRPV1 receptor antagonist. A-889425 blocks TRPV1 channels with an IC50 of 335 nM (rat) and 34 nM (human).

Cat. No.

A13560

CAS No.

36945-98-9

Icilin

Synonyms: AG 3-5

Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM)

Cat. No.

A13585

CAS No.

110683-10-8

ACA

Synonyms: N-(p-amylcinnamoyl) Anthranilic Acid

ACA is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 uM, respectively).

Cat. No.

A13802

CAS No.

57-66-9

Probenecid

Synonyms: Benemid

Probenecid is a selective inhibitor of bacterial growth, primarily targeting pannexin 1 channels, while also exhibiting activity as a TRPV2 channel agonist. Its ability to modulate ion channel activity makes it valuable for research into pain pathways and inflammatory responses. Probenecid is commonly used in studies investigating the role of TRPV2 in nociception and as a tool in exploring bacterial resistance mechanisms.

Cat. No.

A13995

CAS No.

19309-14-9

(E)-Cardamonin

Synonyms: (E)-Cardamomin; (E)-Alpinetin chalcone

(E)-Cardamonin is a selective antagonist of the human transient receptor potential ankyrin 1 (hTRPA1) channel, exhibiting an IC50 of 454 nM. This compound is instrumental in research involving nociception and inflammatory pain models, facilitating studies of sensory signaling pathways. Its role in modulating hTRPA1 activity makes it a valuable reagent for exploring channel-related physiological and pathological processes.

Cat. No.

A13996

CAS No.

1332708-14-1

PF-4840154

Synonyms: PF4840154.

PF-4840154 is a non-electrophilic reference agonist of the TrpA1 channel. The TRPA1 channel is considered an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of pain behaviors in some pre-clinical development models.

Cat. No.

A14093

CAS No.

460746-46-7

ABT-239

ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

Cat. No.

A14126

CAS No.

332117-28-9

TCS 5861528

TCS 5861528 is a TRPA1 channel blocker and an antagonizer of AITC- and 4-HNE-evoked calcium influx.

Cat. No.

A14201

CAS No.

1336960-13-4

GSK-2193874

GSK2193874 was identified as a selective, orally active TRPV4 blocker that inhibits Ca(2+) influx through recombinant TRPV4 channels and native endothelial TRPV4 currents.

Cat. No.

A15496

CAS No.

68171-52-8

Linoleyl ethanolamide

Synonyms: AC1L1D3X

Linoleylethanolamide is an endocannabinoid that also binds to TRPV1 (Ki = 5.60 uM).

Cat. No.

A15497

CAS No.

20675-51-8

Cannabichromene

Synonyms: Cannanbichromene

Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1). Both endocannabinoids and TRPA1 may modulate gastrointestinal motility.

Cat. No.

A15498

CAS No.

212200-21-0

MRS1477

MRS1477 is a TRPV1 positive allosteric modulator.

Cat. No.

A15556

CAS No.

5465-86-1

ML204

ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.