Estrogen receptor modulator 11

Catalog No.: A85246
ER Modulator
Estrogen Receptor Modulator 11 is a tetrahydroisoquinoline derivative that selectively targets estrogen receptors (ER). It demonstrates affinity for both ERα and ERβ, with IC50 values of 285 nM and 421 nM, respectively. Notably, Estrogen Receptor Modulator 11 exhibits no antagonist activity in the MCF-7 cellular assay, indicating potential as a selective modulator in estrogen-related research applications. This compound is valuable for studies focused on ER signaling pathways and related therapeutic developments.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
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Nature volume 610, pages540-546 (2022)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionEstrogen Receptor Modulator 11 is a tetrahydroisoquinoline derivative that selectively targets estrogen receptors (ER). It demonstrates affinity for both ERα and ERβ, with IC50 values of 285 nM and 421 nM, respectively. Notably, Estrogen Receptor Modulator 11 exhibits no antagonist activity in the MCF-7 cellular assay, indicating potential as a selective modulator in estrogen-related research applications. This compound is valuable for studies focused on ER signaling pathways and related therapeutic developments.
Product Information
Catalog NumA85246
FormulaC21H18FNO
Molecular Weight319.37
CAS Number96719-63-0
SMILESFC1=CC=C(C2C3=CC=C(C=C3CCN2C4=CC=CC=C4)O)C=C1
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