Etazolate hydrochloride is a selective inhibitor of type 4 phosphodiesterase (PDE4) with a reported IC50 of 2 μM. This compound acts as a γ-aminobutyric acid A (GABAA) receptor modulator and promotes the activation of α-secretase, leading to enhanced production of soluble amyloid precursor protein (sAPPα). As a pyrazolopyridine derivative, Etazolate hydrochloride increases intracellular cAMP levels and exhibits anxiolytic, antidepressant, and anti-inflammatory properties. It is a valuable tool for research applications focused on mood disorders, neurodegenerative diseases, and inflammation.
Etazolate hydrochloride is a selective inhibitor of type 4 phosphodiesterase (PDE4) with a reported IC50 of 2 μM. This compound acts as a γ-aminobutyric acid A (GABAA) receptor modulator and promotes the activation of α-secretase, leading to enhanced production of soluble amyloid precursor protein (sAPPα). As a pyrazolopyridine derivative, Etazolate hydrochloride increases intracellular cAMP levels and exhibits anxiolytic, antidepressant, and anti-inflammatory properties. It is a valuable tool for research applications focused on mood disorders, neurodegenerative diseases, and inflammation.
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