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Everolimus (RAD001)

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mTOR inhibitor

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Catalog No. A10374

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Everolimus 10mg A10374-10

Regular Price: €57.00

Special Price: €51.30

Everolimus 25mg A10374-25

Regular Price: €114.00

Special Price: €102.60

Everolimus 50mg A10374-50

Regular Price: €190.00

Special Price: €171.00

Everolimus 100mg A10374-100

Regular Price: €304.00

Special Price: €273.60

Everolimus (RAD001) 10mM * 1mL in DMSO A10374-10mM-D

Regular Price: €110.20

Special Price: €99.18

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

Everolimus (RAD001)

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Publications citing Adooq Products
Everolimus (RAD001) Citations (3)
  • Nachi Namatame,et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141-35161 30416685
  • Hirosumi Tamura,et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 29917168
  • Rieko Ohki,et al. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors, Proc Natl Acad Sci U S A., 2014, 111(23): E2404-E2413. 24912192

Chemical Information

Catalog Num A10374
Actions Inhibitor
M. Wt 958.2
Formula C53H83NO14
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 159351-69-6
Synonyms SDZ-RAD, Certican, Zortress, Afinitor
SMILES code C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C/C=C/[[email protected]](C[[email protected]](C(=O)[[email protected]@H]([[email protected]@H](/C(=C/[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]](C)C[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
Chemical Name dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

Biological Activity

Description
Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
Targets
mTOR (FKBP12) (Cell-free assay)
1.6 nM-2.4 nM

Solubility

Solubility (25°C) * In vitro DMSO 30 mg/mL (31.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (7.3 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.44 mL 52.18 mL 104.36mL
0.5 mM 2.09 mL 10.44 mL 20.87 mL
1 mM 1.04 mL 5.22 mL 10.44 mL
5 mM 0.21 mL 1.04 mL 2.09 mL

*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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