Everolimus (RAD001)

Catalog No.: A10374

mTOR inhibitor

Everolimus (RAD001)

Everolimus (RAD001) Chemical Structure

CAS NO. 159351-69-6

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

Availability: In stock

Package Price Qty
10 mg
$60.00
50 mg
$105.00
100 mg
$135.00
10mM * 1mL in DMSO
$116.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
  • Nachi Namatame, .et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Rieko Ohki, .et al. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors, Proc Natl Acad Sci U S A., 2014, 111(23): E2404-E2413. PMID: 24912192

Biological Activity

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
Targets
mTOR (FKBP12) (Cell-free assay)
1.6 nM-2.4 nM
In vitro (25°C) DMSO 30 mg/mL (31.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (7.3 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.44 mL 52.18 mL 104.36 mL
0.5 mM 2.09 mL 10.44 mL 20.87 mL
1 mM 1.04 mL 5.22 mL 10.44 mL
5 mM 0.21 mL 1.04 mL 2.09 mL

*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10374
Actions Inhibitor
M. Wt 958.2
Formula C53H83NO14
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 159351-69-6
Synonyms SDZ-RAD, Certican, Zortress, Afinitor
SMILES C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C/C=C/[[email protected]](C[[email protected]](C(=O)[[email protected]@H]([[email protected]@H](/C(=C/[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]](C)C[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC

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