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- Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
- Nachi Namatame, .et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141每35161 PMID: 30416685
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168
- Rieko Ohki, .et al. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors, Proc Natl Acad Sci U S A., 2014, 111(23): E2404每E2413. PMID: 24912192
|Storage||at -20°C 3 years Powder|
|Synonyms||SDZ-RAD, Certican, Zortress, Afinitor|
|SMILES||C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C/C=C/[[email protected]](C[[email protected]](C(=O)[[email protected]@H]([[email protected]@H](/C(=C/[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]](C)C[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC|
|Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.|
|Solubility (25°C) *||In vitro||DMSO||30 mg/mL (31.3 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||7 mg/mL (7.3 mM)|
|In vivo||30% propylene glycol, 5% Tween 80, 65% D5W||5 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||10.44 mL||52.18 mL||104.36mL|
|0.5 mM||2.09 mL||10.44 mL||20.87 mL|
|1 mM||1.04 mL||5.22 mL||10.44 mL|
|5 mM||0.21 mL||1.04 mL||2.09 mL|
*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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