Everolimus (RAD001)

Name: Everolimus (RAD001)
SKU: A10374
Price: 60 USD
Rating: 5 (10 reviews)

Catalog No.: A10374

mTOR inhibitor

Adooq's Everolimus (RAD001) has been cited by 10 publications

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

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Grouped product items
Product Name	Price	Stock
Everolimus 10mg	$60.00	In stock
Everolimus 50mg	$105.00	In stock
Everolimus 100mg	$135.00	In stock
*Everolimus (RAD001) 10mM 1mL in DMSO**	$116.00	In stock
Bulk Size	Bulk Discount

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Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

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Adooq Products cited in reputable paper

Adooq's Everolimus (RAD001) has been cited by 10 publications

Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591

Ming-Chun Hung, .et al. , Cell Biosci, 2022, 12: 122 PMID: 35918763

Yusuke Murase, .et al. , Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890

Gabriela Torres-Flores, .et al. , Adv Polym Technol, 2020, ID 5462949

Takaaki Fujimura, .et al. , Cancer Biol Ther, 2020, Sep 1;21(9):863-870 PMID: 32835580

BD Henriksbo, .et al. , Am J Physiol Endocrinol Metab, 2020, Jul 1;319(1):E110-E116 PMID: 32421368

Hiroshi Fukamachi, .et al. , J Exp Clin Cancer Res, 2019, 38:127 PMID: 30866995

Nachi Namatame, .et al. , Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685

Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Rieko Ohki, .et al. , Proc Natl Acad Sci U S A, 2014, 111(23): E2404-E2413 PMID: 24912192

Biological Activity

Discription

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

Targets

Target	Value

Product Information

Catalog Num	A10374
Formula	C53H83NO14
Molecular Weight	958.2
CAS Number	159351-69-6
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
Synonyms	SDZ-RAD, Certican, Zortress, Afinitor
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	91 mg/mL (94.97 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (6.26 mM)
In vivo	30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.44 mL	52.18 mL	104.36 mL
0.5 mM	2.09 mL	10.44 mL	20.87 mL
1 mM	1.04 mL	5.22 mL	10.44 mL
5 mM	0.21 mL	1.04 mL	2.09 mL

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