Everolimus (RAD001)

Name: Everolimus (RAD001)
SKU: A10374
Price: 30 USD
Rating: 5 (10 reviews)

Catalog No.: A10374

mTOR inhibitor

Adooq's Everolimus (RAD001) has been cited by 10 publications

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

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Grouped product items
Size	Price	Stock
5mg	$30.00	In stock
10mg	$45.00	In stock
25mg	$70.00	In stock
50mg	$90.00	In stock
100mg	$115.00	In stock
250mg	$200.00	In stock
500mg	$305.00	In stock
*10mM 1mL in DMSO**	$45.00	In stock
Bulk Size	Bulk Discount

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Data Sheet

SDS

Adooq Products cited in reputable paper

Adooq's Everolimus (RAD001) has been cited by 10 publications

Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591

Ming-Chun Hung, .et al. , Cell Biosci, 2022, 12: 122 PMID: 35918763

Yusuke Murase, .et al. , Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890

Gabriela Torres-Flores, .et al. , Adv Polym Technol, 2020, ID 5462949

Takaaki Fujimura, .et al. , Cancer Biol Ther, 2020, Sep 1;21(9):863-870 PMID: 32835580

BD Henriksbo, .et al. , Am J Physiol Endocrinol Metab, 2020, Jul 1;319(1):E110-E116 PMID: 32421368

Hiroshi Fukamachi, .et al. , J Exp Clin Cancer Res, 2019, 38:127 PMID: 30866995

Nachi Namatame, .et al. , Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685

Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Rieko Ohki, .et al. , Proc Natl Acad Sci U S A, 2014, 111(23): E2404-E2413 PMID: 24912192

Biological Activity

Discription

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A10374
Formula	C53H83NO14
Molecular Weight	958.2
CAS Number	159351-69-6
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
Synonyms	SDZ-RAD, Certican, Zortress, Afinitor
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	91 mg/mL (94.97 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (6.26 mM)
In vivo	30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.44 mL	52.18 mL	104.36 mL
0.5 mM	2.09 mL	10.44 mL	20.87 mL
1 mM	1.04 mL	5.22 mL	10.44 mL
5 mM	0.21 mL	1.04 mL	2.09 mL

Useful Calculator

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