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ALK4/ALK5 inhibitor

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Catalog No. A14213

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
EW-7197 5mg A14213-5

Regular Price: €123.50

Special Price: €111.15

EW-7197 10mg A14213-10

Regular Price: €209.00

Special Price: €188.10

EW-7197 25mg A14213-25

Regular Price: €418.00

Special Price: €376.20

EW-7197 10mM * 1mL in DMSO A14213-10mM-D

Regular Price: €108.30

Special Price: €97.47

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively


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Publications citing Adooq Products
EW-7197 Citations (1)
  • Morita T, .et al. Tumor Progression Is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis, Mol Cancer Res, 2018, May;16(5):880-893 PMID: 29330296

Chemical Information

Catalog Num A14213
Actions Inhibitor
M. Wt 399.42
Formula C22H18FN7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1352608-82-2
Synonyms EW7197

Biological Activity

EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
Target Value
ALK5IC50: 11nM
ALK4IC50: 13nM
ALK1IC50: >10μM
ALK2IC50: >10μM
ALK3IC50: >10μM
ALK6IC50: >10μM


Solubility (25°C)* In vitro DMSO 79 mg/mL (197.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (107.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.04 mL 125.18 mL 250.36mL
0.5 mM 5.01 mL 25.04 mL 50.07 mL
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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