EX 527 (Selisistat)

Name: EX 527 (Selisistat)
Brand: Adooq Bioscience
SKU: A10377
Rating: 100 (5 reviews)

Catalog No.: A10377

SIRT1 inhibitor

Product Citations (5)

EX 527 (Selisistat) Chemical Structure

CAS NO. 49843-98-3

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.

Availability: In stock

Package	Price	Qty
5 mg	$25.00
10 mg	$40.00
25 mg	$70.00
100 mg	$200.00
10mM * 1mL in DMSO	$71.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq EX 527 (Selisistat)

Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
Bugga Paramesha, .et al. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function, Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847

Biological Activity

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.

Targets

SIRT1 (Cell-free assay)
38 nM

Solubility *

In vitro (25°C)	DMSO	46 mg/mL (184.95 mM)
	Water	Insoluble
	Ethanol	17 mg/mL (68.35 mM)
In vivo	5% DMSO+30% PEG 300+ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.21 mL	201.05 mL	402.09 mL
0.5 mM	8.04 mL	40.21 mL	80.42 mL
1 mM	4.02 mL	20.1 mL	40.21 mL
5 mM	0.8 mL	4.02 mL	8.04 mL

*The above data is based on the productmolecular weight 248.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10377
Actions	Inhibitor
CAS No.	49843-98-3
Formula	C13H13ClN2O
M. Wt	248.7
Purity	>98%
Synonyms	EX527, EX-527
SMILES	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.