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- Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
- Bugga Paramesha, .et al. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function, Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
- Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
- Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847
Biological Activity
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.
Targets
SIRT1 (Cell-free assay) | ||||
38 nM |
In vitro (25°C) | DMSO | 46 mg/mL (184.95 mM) | |
Water | Insoluble | ||
Ethanol | 17 mg/mL (68.35 mM) | ||
In vivo | 5% DMSO+30% PEG 300+ddH2O | 14 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 40.21 mL | 201.05 mL | 402.09 mL |
0.5 mM | 8.04 mL | 40.21 mL | 80.42 mL |
1 mM | 4.02 mL | 20.1 mL | 40.21 mL |
5 mM | 0.8 mL | 4.02 mL | 8.04 mL |
*The above data is based on the productmolecular weight 248.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10377 |
---|---|
Actions | Inhibitor |
CAS No. | 49843-98-3 |
Formula | C13H13ClN2O |
M. Wt | 248.7 |
Purity | >98% |
Synonyms | EX527, EX-527 |
SMILES | C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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