EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.
Targets
Target
Value
Chemical Information
Catalog Num
A10377
Formula
C13H13ClN2O
Molecular Weight
248.7
CAS Number
49843-98-3
SMILES
C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
Synonyms
EX527, EX-527
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
46 mg/mL (184.95 mM)
Water
Insoluble
Ethanol
17 mg/mL (68.35 mM)
In vivo
5% DMSO+30% PEG 300+ddH2O
14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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