EX 527 (Selisistat)

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.
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Product Name Price Stock Qty
EX 527 5mg
Special Price $20.00 Regular Price $25.00
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EX 527 10mg
Special Price $32.00 Regular Price $40.00
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EX 527 25mg
Special Price $56.00 Regular Price $70.00
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EX 527 100mg
Special Price $160.00 Regular Price $200.00
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EX 527 10mM * 1mL in DMSO
Special Price $56.80 Regular Price $71.00
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's EX 527 (Selisistat) has been cited by 7 publications
  • Qiang Chen, .et al. , J Bioenerg Biomembr, 2022, Feb;55(1):33-42 PMID: 36525212
  • Flavien Bizot, .et al. , Mol Ther Nucleic Acids, 2022, Nov 21;30:606-620 PMID: 36514350
  • Takeshi Nakamura, .et al. , Shimane Journal of Medical Science, 2022, 38 (2), 59-66
  • Bugga Paramesha, .et al. , Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
  • Wenhui Yao, .et al. , J Cell Physiol, 2020, 07 August
  • Guang Bai, .et al. , Epigenetics of Chronic Pain, 2019, Pages 1-48
  • Yoshikawa A, .et al. , J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847
  • Biological Activity
    Discription EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.
    Targets
    Target Value
    Product Information
    Catalog Num A10377
    Formula C13H13ClN2O
    Molecular Weight 248.7
    CAS Number 49843-98-3
    SMILES C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 46 mg/mL (184.95 mM)
    Water Insoluble
    Ethanol 17 mg/mL (68.35 mM)
    In vivo 5% DMSO+30% PEG 300+ddH2O 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 40.21 mL 201.05 mL 402.09 mL
    0.5 mM 8.04 mL 40.21 mL 80.42 mL
    1 mM 4.02 mL 20.1 mL 40.21 mL
    5 mM 0.8 mL 4.02 mL 8.04 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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