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$0.00 - Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
- Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847
Biological Activity
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.
Targets
| SIRT1 (Cell-free assay) | ||||
| 38 nM |
| In vitro (25°C) | DMSO | 50 mg/mL (201.03 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 18 mg/mL (72.37 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 14 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.21 mL | 201.05 mL | 402.09 mL |
| 0.5 mM | 8.04 mL | 40.21 mL | 80.42 mL |
| 1 mM | 4.02 mL | 20.1 mL | 40.21 mL |
| 5 mM | 0.8 mL | 4.02 mL | 8.04 mL |
*The above data is based on the productmolecular weight 248.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10377 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 248.7 |
| Formula | C13H13ClN2O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 49843-98-3 |
| Synonyms | EX527, EX-527 |
| SMILES | C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N |
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