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EX 527 (Selisistat)

EX 527 (Selisistat)

Name: EX 527 (Selisistat)
Brand: Adooq Bioscience
SKU: A10377
Rating: 100 (2 reviews)

Catalog No.: A10377

SIRT1 inhibitor

Product Citations (2)

EX 527 (Selisistat) Chemical Structure

CAS NO. 49843-98-3

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.

Availability: In stock

Package	Price	Qty
5 mg	$25.00
10 mg	$40.00
25 mg	$70.00
100 mg	$200.00
10mM * 1mL in DMSO	$71.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq EX 527 (Selisistat)

Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847

Biological Activity

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.

Targets

SIRT1 (Cell-free assay)
38 nM

Solubility *

In vitro (25°C)	DMSO	50 mg/mL (201.03 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	18 mg/mL (72.37 mM)
In vivo	1% DMSO/30% polyethylene glycol/1% Tween 80	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.21 mL	201.05 mL	402.09 mL
0.5 mM	8.04 mL	40.21 mL	80.42 mL
1 mM	4.02 mL	20.1 mL	40.21 mL
5 mM	0.8 mL	4.02 mL	8.04 mL

*The above data is based on the productmolecular weight 248.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10377
Actions	Inhibitor
M. Wt	248.7
Formula	C13H13ClN2O
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	49843-98-3
Synonyms	EX527, EX-527
SMILES	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N