ex229 (compound 991)

Catalog No.: A16795

AMPK activator

ex229 (compound 991)

ex229 (compound 991) Chemical Structure

CAS NO. 1219739-36-2

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • CN Koyani, .et al. Empagliflozin Protects Heart From Inflammation and Energy Depletion via AMPK Activation, Pharmacol Res, 2020, May 17;158:104870 PMID: 32434052

Biological Activity

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.
In vitro DMSO 11 mg/mL (25.47 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.16 mL 115.78 mL 231.55 mL
0.5 mM 4.63 mL 23.16 mL 46.31 mL
1 mM 2.32 mL 11.58 mL 23.16 mL
5 mM 0.46 mL 2.32 mL 4.63 mL

*The above data is based on the productmolecular weight 431.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16795
Actions Activator
CAS No. 1219739-36-2
Formula C24H18ClN3O3
M. Wt 431.87
Purity >98%
Synonyms ex-229, ex 229
SMILES CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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