AMPK

Cat. No.

A11071

CAS No.

844499-71-4

A-769662

A-769662 is a new activator of AMP-activated protein kinase (AMPK).

Cat. No.

A11970

CAS No.

866405-64-3

Dorsomorphin (BML-275)

Synonyms: BML275

BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor.

Cat. No.

A10028

CAS No.

2627-69-2

Acadesine (Aicar, NSC 105823)

Synonyms: AICA-riboside; Aicar; NSC 105823

Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

Cat. No.

A13720

CAS No.

1219168-18-9

Dorsomorphin 2HCl

Synonyms: Compound C; BML-275

Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.

Cat. No.

A11622

CAS No.

657-24-9

Metformin

Synonyms: 1,1-Dimethylbiguanide

Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.

Cat. No.

A15896

CAS No.

1346607-05-3

GSK621

GSK621 is a potent and selective AMPK agonist.

Cat. No.

A16795

CAS No.

1219739-36-2

ex229 (compound 991)

Synonyms: compound 991

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.

Cat. No.

A10717

CAS No.

834-28-6

Phenformin hydrochloride

Phenformin hydrochloride is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity.

Cat. No.

A13392

CAS No.

1394371-71-1

MK8722

MK8722 is a potent and systemic pan-AMPK activator.

Cat. No.

A14312

CAS No.

1214265-58-3

WZ4003

WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2

Cat. No.

A14475

CAS No.

23513-15-7

10-Gingerol

10-Gingerol is an AMPK agonist derived from ginger oleoresin, exhibiting notable anti-inflammatory, antioxidant, and anti-proliferative properties. It effectively suppresses neointimal hyperplasia and inhibits the proliferation of vascular smooth muscle cells. Demonstrating significant radical scavenging activities, 10-Gingerol has IC50 values of 10.47 μM against DPPH, 1.68 μM against superoxide, and 1.35 μM against hydroxyl radicals. This compound also inhibits MDA-MB-231 tumor cell line proliferation with an IC50 of 12.1 μM, while targeting the PI3K/Akt signaling pathway to suppress proliferation, migration, invasion, and promote apoptosis. It holds potential for research applications in ulcerative colitis.

Cat. No.

A14749

CAS No.

53452-16-7

Vaccarin

Vaccarin, a flavonoid glycoside, is considered one of the major active constituents of Vaccaria segetalis.

Cat. No.

A15571

CAS No.

117-10-2

Danthron

Synonyms: Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

Danthron is an AMPK activator that plays a critical role in regulating glucose and lipid metabolism. Derived from the traditional Chinese medicinal plant Salvia miltiorrhiza Bunge, Danthron has demonstrated potential in enhancing cellular energy balance. Its biological activity makes it a valuable reagent for research in metabolic disorders and related therapeutic applications.

Cat. No.

A15815

CAS No.

738606-46-7

ETC-1002

Synonyms: ESP-55016

ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

Cat. No.

A16281

CAS No.

1613724-42-7

HTH-01-015

HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members.

Cat. No.

A16284

CAS No.

1273323-67-3

YLF-466D

Synonyms: C24

YLF-466D is an allosteric AMPK activator.

Cat. No.

A16801

CAS No.

1467057-23-3

PF-06409577

PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.

Cat. No.

A17063

CAS No.

1219737-12-8

MK-3903

MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice.

Cat. No.

A17097

CAS No.

1621-56-3

7-Methoxyisoflavone

7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).

Cat. No.

A19492

CAS No.

1314893-26-9

MARK-IN-2

MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM.

Cat. No.

A19503

CAS No.

1109283-93-3

MARK-IN-1

MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of

Cat. No.

A19807

CAS No.

1261289-04-6

O-304

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK.

Cat. No.

A20304

CAS No.

148411-57-8

Chitosan oligosaccharide

Synonyms: COS

Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.

Cat. No.

A20760

CAS No.

52029-86-4

STO-609

STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively.

Cat. No.

A21963

CAS No.

723249-01-2

ZLN024

ZLN024 is an AMPK allosteric activator.