Catalog No.
Product Name
Application
Product Information
Product Citation
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AMPK activator
Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.
- R. Lim, .et al. , Placenta, 2015, Apr;36(4):454-62 PMID: 25659498
- Stella Liong, .et al. , J Physiol Biochem, 2015, Dec;71(4):703-17 PMID: 26407807
- Phenformin hydrochloride is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity.
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AMPK activator
A-769662 is a new activator of AMP-activated protein kinase (AMPK).- Daniel Missailidis, .et al. , Int J Mol Sci., 2021, Feb; 22(4): 2046 PMID: 33669532
- Lieberthal W, .et al. , Am J Physiol Renal Physiol, 2019, 2019 PMID: 30995114
- Kikuchi H, .et al. , Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
- Schneider H, .et al. , Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200
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AMPK inhibitor
BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor.- Yang PM, .et al. , Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
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BMP inhibitor
Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.- Kameshima S, .et al. , Apoptosis, 2019, Feb 8 PMID: 30737648
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AMPK activator
GSK621 is a potent and selective AMPK agonist.- Harvey W. Smith, .et al. , Nat Commun, 2019, 10, 2901(2019) PMID: 31263101
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NUAK1 inhibitor
HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. -
AMPK activator
EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.- CN Koyani, .et al. , Pharmacol Res, 2020, May 17;158:104870 PMID: 32434052
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AMPK activator
PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms. -
AMPK activator
PF-06679142 is a potent AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption, low plasma clearance, and negligible renal clearance in preclinical species.
