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- Nihei W, .et al. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains, J Lipid Res, 2018, Nov; 59(11): 2181-2187 PMID: 30242108
Biological Activity
Ezetimibe is a compound that lowers cholesterol. It acts by decreasing cholesterol absorption in the intestine. Ezetimibe localises at the brush border of the small intestine, where ezetimibe inhibits the absorption of cholesterol from the intestine.
| In vitro (25°C) | DMSO | 75 mg/mL (183.19 mM) | |
| Water | Insoluble | ||
| Ethanol | 75 mg/mL (183.19 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.43 mL | 122.13 mL | 244.26 mL |
| 0.5 mM | 4.89 mL | 24.43 mL | 48.85 mL |
| 1 mM | 2.44 mL | 12.21 mL | 24.43 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.89 mL |
*The above data is based on the productmolecular weight 409.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10379 |
|---|---|
| CAS No. | 163222-33-1 |
| Formula | C24H21F2NO3 |
| M. Wt | 409.4 |
| Purity | >98% |
| Synonyms | Zetia , Ezetrol |
| SMILES | C1=CC(=CC=C1[[email protected]@H]2[[email protected]](C(=O)N2C3=CC=C(C=C3)F)CC[[email protected]@H](C4=CC=C(C=C4)F)O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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