EZH2-IN-16 is a potent inhibitor of the histone methyltransferase EZH2, targeting both the wild-type and the Y641F mutant forms with IC50 values of 37.6 nM and 79.1 nM, respectively. This compound effectively inhibits the proliferation of WSU-DLCL2 cells, demonstrating a GI50 of 0.2 μM. EZH2-IN-16 is valuable for research applications focused on epigenetic regulation and oncology, particularly in the context of EZH2-related pathways in cancer progression.
EZH2-IN-16 is a potent inhibitor of the histone methyltransferase EZH2, targeting both the wild-type and the Y641F mutant forms with IC50 values of 37.6 nM and 79.1 nM, respectively. This compound effectively inhibits the proliferation of WSU-DLCL2 cells, demonstrating a GI50 of 0.2 μM. EZH2-IN-16 is valuable for research applications focused on epigenetic regulation and oncology, particularly in the context of EZH2-related pathways in cancer progression.
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