EZH2-IN-23 is a selective inhibitor of the EZH2 enzyme, exhibiting potent inhibition of the PRC2 complex with an IC50 of 0.8 nM. It effectively reduces H3K27 trimethylation in cellular assays with an IC50 of 40 nM, making it a valuable tool for studying epigenetic regulation. Additionally, EZH2-IN-23 demonstrates favorable pharmacokinetic properties in rat models, featuring 100% oral bioavailability, which enhances its potential for in vivo research applications.
EZH2-IN-23 is a selective inhibitor of the EZH2 enzyme, exhibiting potent inhibition of the PRC2 complex with an IC50 of 0.8 nM. It effectively reduces H3K27 trimethylation in cellular assays with an IC50 of 40 nM, making it a valuable tool for studying epigenetic regulation. Additionally, EZH2-IN-23 demonstrates favorable pharmacokinetic properties in rat models, featuring 100% oral bioavailability, which enhances its potential for in vivo research applications.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
