Fasudil mesylate is a potent RhoA/ROCK inhibitor with a Ki value of 0.33 μM for ROCK1 and IC50 values of 0.158 μM for ROCK2, along with notable inhibition of PKA, PKC, and PKG. This orally active compound also acts as a calcium channel antagonist and vasodilator, demonstrating significant potential in cardiovascular research and the study of cellular signaling pathways. Its diverse inhibitory effects make Fasudil mesylate a valuable tool for investigating RhoA/ROCK-related biological processes.
Fasudil mesylate is a potent RhoA/ROCK inhibitor with a Ki value of 0.33 μM for ROCK1 and IC50 values of 0.158 μM for ROCK2, along with notable inhibition of PKA, PKC, and PKG. This orally active compound also acts as a calcium channel antagonist and vasodilator, demonstrating significant potential in cardiovascular research and the study of cellular signaling pathways. Its diverse inhibitory effects make Fasudil mesylate a valuable tool for investigating RhoA/ROCK-related biological processes.
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