Ficerafusp alfa is a bispecific antibody targeting EGFR and TGFβ with a Kd of 2.58 nM for EGFR and 61.3 nM for TGFβ1. This compound inhibits EGFR phosphorylation, thereby blocking EGF-dependent cell proliferation and facilitating antibody-dependent cellular cytotoxicity in EGFR-positive tumor cells. Additionally, Ficerafusp alfa sequesters TGFβ via its TGFβRII ECD domain, neutralizing TGFβ activity and inhibiting TGFβ-dependent processes such as epithelial-mesenchymal transition. This reagent is valuable for research on head and neck squamous cell carcinoma, advanced solid tumors, and various cancers including squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer.
Ficerafusp alfa is a bispecific antibody targeting EGFR and TGFβ with a Kd of 2.58 nM for EGFR and 61.3 nM for TGFβ1. This compound inhibits EGFR phosphorylation, thereby blocking EGF-dependent cell proliferation and facilitating antibody-dependent cellular cytotoxicity in EGFR-positive tumor cells. Additionally, Ficerafusp alfa sequesters TGFβ via its TGFβRII ECD domain, neutralizing TGFβ activity and inhibiting TGFβ-dependent processes such as epithelial-mesenchymal transition. This reagent is valuable for research on head and neck squamous cell carcinoma, advanced solid tumors, and various cancers including squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer.
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