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Filgotinib

Filgotinib

Name: Filgotinib
Brand: Adooq Bioscience
SKU: A14232
Rating: 100 (268 reviews)

Catalog No.: A14232

JAK inhibitor

Filgotinib Chemical Structure

CAS NO. 1206161-97-8

Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

Availability: In stock

Package	Price	Qty
10 mg	$110.00
25 mg	$180.00
50 mg	$280.00
10mM * 1mL in DMSO	$75.00
Custom Size	Get quote

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Biological Activity

Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

Targets

JAK1	JAK2	TYK2	JAK3
10 nM	28 nM	116 nM	810 nM

Solubility *

In vitro (25°C)	DMSO	75 mg/mL (176.26 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.5 mL	117.51 mL	235.02 mL
0.5 mM	4.7 mL	23.5 mL	47 mL
1 mM	2.35 mL	11.75 mL	23.5 mL
5 mM	0.47 mL	2.35 mL	4.7 mL

*The above data is based on the productmolecular weight 425.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A14232
Actions	Inhibitor
CAS No.	1206161-97-8
Formula	C21H23N5O3S
M. Wt	425.5
Purity	>98%
Synonyms	GLPG0634
SMILES	C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.