Filgotinib

Catalog No.: A14232

JAK inhibitor

Filgotinib

Filgotinib Chemical Structure

CAS NO. 1206161-97-8

Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $110.00

Special Price $99.00

25 mg

Regular Price: $180.00

Special Price $162.00

50 mg

Regular Price: $280.00

Special Price $252.00

10mM * 1mL in DMSO

Regular Price: $75.00

Special Price $67.50

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Targets
JAK1 JAK2 TYK2 JAK3
10 nM28 nM116 nM810 nM
In vitro DMSO 85 mg/mL (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.5 mL 117.51 mL 235.02 mL
0.5 mM 4.7 mL 23.5 mL 47 mL
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL

*The above data is based on the productmolecular weight 425.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14232
Actions Inhibitor
M. Wt 425.5
Formula C21H23N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1206161-97-8
Synonyms GLPG0634
SMILES C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

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