Firocoxib-d4 is a deuterium-labeled derivative of Firocoxib, acting primarily as a selective inhibitor of cyclooxygenase-2 (COX-2). With an IC50 value of 0.13 μM, Firocoxib demonstrates a notable selectivity, being 58-fold more potent against COX-2 compared to COX-1 (IC50 of 7.5 μM). This compound is primarily utilized in research to investigate COX-2's role in inflammation and associated therapeutic targets. Its stable isotope labeling allows for advanced studies in pharmacokinetics and metabolism in biological systems.
Firocoxib-d4 is a deuterium-labeled derivative of Firocoxib, acting primarily as a selective inhibitor of cyclooxygenase-2 (COX-2). With an IC50 value of 0.13 μM, Firocoxib demonstrates a notable selectivity, being 58-fold more potent against COX-2 compared to COX-1 (IC50 of 7.5 μM). This compound is primarily utilized in research to investigate COX-2's role in inflammation and associated therapeutic targets. Its stable isotope labeling allows for advanced studies in pharmacokinetics and metabolism in biological systems.
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