Flindokalner is a potassium channel modulator that positively influences all neuronal Kv7 channel subtypes expressed in HEK293 cells, alongside acting as a positive modulator of large conductance calcium-activated potassium channels (BKca). It exhibits negative modulatory activity at Kv7.1 channels with a Ki of 3.7 μM and also negatively modulates GABAA receptors. In vivo studies demonstrate its anxiolytic efficacy, making it a valuable reagent for research in neuropharmacology and the study of ion channel function.
Flindokalner is a potassium channel modulator that positively influences all neuronal Kv7 channel subtypes expressed in HEK293 cells, alongside acting as a positive modulator of large conductance calcium-activated potassium channels (BKca). It exhibits negative modulatory activity at Kv7.1 channels with a Ki of 3.7 μM and also negatively modulates GABAA receptors. In vivo studies demonstrate its anxiolytic efficacy, making it a valuable reagent for research in neuropharmacology and the study of ion channel function.
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