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$0.00 - Irene Dell'Anno, .et al. Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma, Invest New Drugs, 2020, Dec 9 PMID: 33300108
Biological Activity
Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells.
Targets
| STAT1 (Vascular smooth muscle cells) | ||||
| In vitro (25°C) | DMSO | 52 mg/mL (182.3 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.06 mL | 175.32 mL | 350.63 mL |
| 0.5 mM | 7.01 mL | 35.06 mL | 70.13 mL |
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
*The above data is based on the productmolecular weight 285.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10396 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 21679-14-1 |
| Formula | C10H12FN5O4 |
| M. Wt | 285.2 |
| Purity | >98% |
| Synonyms | F-ara-A, NSC 118218 |
| SMILES | C1=NC2=C(N=C(N=C2N1[[email protected]]3[[email protected]]([[email protected]@H]([[email protected]](O3)CO)O)O)F)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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