FM-381

Catalog No.: A16805

JAK3 inhibitor

FM-381

FM-381 Chemical Structure

CAS NO. N

FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.

Availability: In stock

Package Price Qty
2 mg
$100.00
5 mg
$190.00
25 mg
$600.00
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Biological Activity

FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.69 mL 233.37 mL
0.5 mM 4.67 mL 23.34 mL 46.67 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.496. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16805
Actions Inhibitor
M. Wt 428.496
Formula C24H24N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. N
Synonyms FM 381, FM381
SMILES O=C(N(C)C)/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5

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