FM-381

Catalog No.: A16805

JAK3 inhibitor

FM-381

FM-381 Chemical Structure

CAS NO. 2226521-65-7

FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.

Availability: In stock

Package Price Qty
2 mg

Regular Price: $100.00

Special Price $80.00

5 mg

Regular Price: $190.00

Special Price $152.00

25 mg

Regular Price: $600.00

Special Price $480.00

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Biological Activity

FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.
In vitro DMSO 20 mg/mL (46.67 mM)
Water Insoluble
Ethanol 2 mg/mL (4.66 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.69 mL 233.37 mL
0.5 mM 4.67 mL 23.34 mL 46.67 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.496. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16805
Actions Inhibitor
CAS No. 2226521-65-7
Formula C24H24N6O2
M. Wt 428.496
Purity >98%
Synonyms FM 381, FM381
SMILES O=C(N(C)C)/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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