Fig. 1 · Structure
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Fmoc-NH-PEG12-CH2CH2COOH
PROTAC Linker
Fmoc-NH-PEG12-CH2CH2COOH is a polyethylene glycol (PEG) based linker designed for the development of PROTAC molecules. This compound facilitates the targeted degradation of proteins by promoting the formation of ternary complexes between E3 ligases and specified protein targets. Its application is crucial in biochemistry and pharmaceutical research focused on innovative therapeutic strategies that harness the ubiquitin-proteasome system for selective protein degradation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1952360-91-6 |
| Applications | PROTAC Linker |
| Formula | C42H65NO16 |
| Molecular Weight | 839.97 |
| SMILES | O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.