Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable linker specifically designed for antibody-drug conjugates (ADCs). This compound features a hydrophilic PEG spacer and a Val-Cit-PAB dipeptide, which enables the selective release of therapeutic payloads inside target cells through proteolytic cleavage. The benzylic alcohol present in the PAB component can readily react with various functional groups for efficient conjugation to drug molecules, while the Fmoc protecting group can be deprotected using piperidine, allowing access to a primary amine for further coupling reactions. This linker is crucial for enhancing the efficacy and specificity of ADCs in biological research and therapeutic applications.
Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable linker specifically designed for antibody-drug conjugates (ADCs). This compound features a hydrophilic PEG spacer and a Val-Cit-PAB dipeptide, which enables the selective release of therapeutic payloads inside target cells through proteolytic cleavage. The benzylic alcohol present in the PAB component can readily react with various functional groups for efficient conjugation to drug molecules, while the Fmoc protecting group can be deprotected using piperidine, allowing access to a primary amine for further coupling reactions. This linker is crucial for enhancing the efficacy and specificity of ADCs in biological research and therapeutic applications.
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