FR 180204

Catalog No.: A14119

ERK inhibitor

FR 180204

FR 180204 Chemical Structure

CAS NO. 865362-74-9

FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.

Availability: In stock

Package Price Qty
10 mg
$120.00
25 mg
$250.00
50 mg
$400.00
10mM * 1mL in DMSO
$95.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
  • Dyshlovoy SA, .et al. Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin, Proteomics, 2017, Jun;17(11) PMID: 28445005

Biological Activity

FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
Targets
ERK2 ERK1
0.14 μM(Ki)0.31 μM(Ki)
In vitro DMSO 57 mg/mL (174.13 mM)
Water Insoluble
Ethanol Warmed: 2 mg/mL (6.1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.55 mL 152.75 mL 305.49 mL
0.5 mM 6.11 mL 30.55 mL 61.1 mL
1 mM 3.05 mL 15.27 mL 30.55 mL
5 mM 0.61 mL 3.05 mL 6.11 mL

*The above data is based on the productmolecular weight 327.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14119
Actions Inhibitor
CAS No. 865362-74-9
Formula C18H13N7
M. Wt 327.34
Purity >98%
Synonyms FR-180204,FR180204
SMILES C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=CC5=C(NN=C5N=N4)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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