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- Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
- Dyshlovoy SA, .et al. Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin, Proteomics, 2017, Jun;17(11) PMID: 28445005
Biological Activity
FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
Targets
| ERK2 | ERK1 | |||
| 0.14 μM(Ki) | 0.31 μM(Ki) |
| In vitro | DMSO | 57 mg/mL (174.13 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 2 mg/mL (6.1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.55 mL | 152.75 mL | 305.49 mL |
| 0.5 mM | 6.11 mL | 30.55 mL | 61.1 mL |
| 1 mM | 3.05 mL | 15.27 mL | 30.55 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.11 mL |
*The above data is based on the productmolecular weight 327.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14119 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 865362-74-9 |
| Formula | C18H13N7 |
| M. Wt | 327.34 |
| Purity | >98% |
| Synonyms | FR-180204,FR180204 |
| SMILES | C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=CC5=C(NN=C5N=N4)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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