FR139317 is a selective antagonist of the endothelin A (ETA) receptor. This compound effectively inhibits cerebral activation induced by endothelin-1 in conscious rat models. Additionally, FR139317 demonstrates the capability to reduce cerebral vasospasm in canine subjects, highlighting its relevance in studies related to vascular regulation and cerebrovascular conditions.
FR139317 is a selective antagonist of the endothelin A (ETA) receptor. This compound effectively inhibits cerebral activation induced by endothelin-1 in conscious rat models. Additionally, FR139317 demonstrates the capability to reduce cerebral vasospasm in canine subjects, highlighting its relevance in studies related to vascular regulation and cerebrovascular conditions.
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