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$0.00 Biological Activity
FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
Targets
| PAK1 | PAK2 | PAK2 | PAK3 | |
| 8 nM | 13 nM | 13 nM | 19 nM |
| In vitro | DMSO | Warmed: 13 mg/mL (23.29 mM) | |
| Water | Insoluble | ||
| Ethanol | 1 mg/mL (1.79 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.92 mL | 89.59 mL | 179.18 mL |
| 0.5 mM | 3.58 mL | 17.92 mL | 35.84 mL |
| 1 mM | 1.79 mL | 8.96 mL | 17.92 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
*The above data is based on the productmolecular weight 558.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12553 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1286739-19-2 |
| Formula | C29H28ClN7OS |
| M. Wt | 558.1 |
| Purity | >98% |
| Synonyms | FRAX 597, FRAX-597 |
| SMILES | CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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