FRAX597

FRAX597 Chemical Structure

CAS NO. 1286739-19-2

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
25 mg
$450.00
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Biological Activity

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
Targets
PAK1 PAK2 PAK2 PAK3
8 nM13 nM13 nM19 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.92 mL 89.59 mL 179.18 mL
0.5 mM 3.58 mL 17.92 mL 35.84 mL
1 mM 1.79 mL 8.96 mL 17.92 mL
5 mM 0.36 mL 1.79 mL 3.58 mL

*The above data is based on the productmolecular weight 558.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12553
Actions Inhibitor
M. Wt 558.1
Formula C29H28ClN7OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1286739-19-2
Synonyms FRAX 597, FRAX-597
SMILES CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C

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