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PAK inhibitor

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Catalog No. A12553

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
FRAX597 5mg A12553-5
FRAX597 10mg A12553-10
FRAX597 25mg A12553-25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).


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Chemical Information

Catalog Num A12553
Actions Inhibitor
M. Wt 558.1
Formula C29H28ClN7OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1286739-19-2
Synonyms FRAX 597, FRAX-597

Biological Activity

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
8 nM13 nM13 nM19 nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.92 mL 89.59 mL 179.18mL
0.5 mM 3.58 mL 17.92 mL 35.84 mL
1 mM 1.79 mL 8.96 mL 17.92 mL
5 mM 0.36 mL 1.79 mL 3.58 mL

*The above data is based on the productmolecular weight 558.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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