Catalog No.
Product Name
Application
Product Information
Product Citation
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PAK4 inhibitor
PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth. -
PAK inhibitor
FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM). -
allosteric PAK1 inhibitor
NVS-PAK1-1 is a potent and selective allosteric PAK1 inhibitor with an IC50 of 5 nM. -
PAK inhibitor
FRAX486 is a small-molecule PAK inhibitor.- Natalia Barraza-Núñez, .et al. , Neurotox Res, 2023, Mar 3 PMID: 36867391
- Yukie Yamahashi, .et al. , Mol Psychiatry, 2022, 03 June
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PAK4/NAMPT Inhibitor
KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
