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FTI-277 HCl

FTase Inhibitor

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Catalog No. A14439

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
FTI-277 HCl 5mg A14439-5
FTI-277 HCl 10mg A14439-10
FTI-277 HCl 25mg A14439-25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.

FTI-277 HCl

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Chemical Information

Catalog Num A14439
Actions Inhibitor
M. Wt 484.07
Formula C22H30ClN3O3S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 180977-34-8
Synonyms FTI 277, FTI277

Biological Activity

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
FTase GGTase I
500 pM50 nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.66 mL 103.29 mL 206.58mL
0.5 mM 4.13 mL 20.66 mL 41.32 mL
1 mM 2.07 mL 10.33 mL 20.66 mL
5 mM 0.41 mL 2.07 mL 4.13 mL

*The above data is based on the productmolecular weight 484.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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