FTI-277 HCl

Catalog No.: A14439
FTase Inhibitor
FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
Grouped product items
Product Name Price Stock Qty
FTI-277 HCl 5mg
$90.00
In stock
FTI-277 HCl 10mg
$150.00
In stock
FTI-277 HCl 25mg
$300.00
In stock
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Biological Activity
Discription FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
Targets
Target Value
Product Information
Catalog Num A14439
Formula C22H30ClN3O3S2
Molecular Weight 484.07
CAS Number 180977-34-8
SMILES COC(=O)[C@H](CCSC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.Cl
Synonyms FTI 277, FTI277
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 90 mg/mL (185.92 mM)
Water 16 mg/mL (33.04 mM)
Ethanol Warmed: 13 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.66 mL 103.29 mL 206.58 mL
0.5 mM 4.13 mL 20.66 mL 41.32 mL
1 mM 2.07 mL 10.33 mL 20.66 mL
5 mM 0.41 mL 2.07 mL 4.13 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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