FTI-277 HCl

Catalog No.: A14439

FTase Inhibitor

FTI-277 HCl Chemical Structure

CAS NO. 180977-34-8

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
25 mg
$300.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
Targets
FTase GGTase I
500 pM50 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.66 mL 103.29 mL 206.58 mL
0.5 mM 4.13 mL 20.66 mL 41.32 mL
1 mM 2.07 mL 10.33 mL 20.66 mL
5 mM 0.41 mL 2.07 mL 4.13 mL

*The above data is based on the productmolecular weight 484.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14439
Actions Inhibitor
M. Wt 484.07
Formula C22H30ClN3O3S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 180977-34-8
Synonyms FTI 277, FTI277
SMILES COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.Cl.Cl

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