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$0.00 Biological Activity
FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
Targets
| FTase | GGTase I | |||
| 500 pM | 50 nM |
| In vitro | DMSO | 90 mg/mL (185.92 mM) | |
| Water | 16 mg/mL (33.04 mM) | ||
| Ethanol | Warmed: 13 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.66 mL | 103.29 mL | 206.58 mL |
| 0.5 mM | 4.13 mL | 20.66 mL | 41.32 mL |
| 1 mM | 2.07 mL | 10.33 mL | 20.66 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.13 mL |
*The above data is based on the productmolecular weight 484.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14439 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 180977-34-8 |
| Formula | C22H30ClN3O3S2 |
| M. Wt | 484.07 |
| Purity | >98% |
| Synonyms | FTI 277, FTI277 |
| SMILES | COC(=O)[[email protected]](CCSC)NC(=O)C1=C(C=C(C=C1)NC[[email protected]](CS)N)C2=CC=CC=C2.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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