FTI-277 HCl

Catalog No.: A14439

FTase Inhibitor

FTI-277 HCl

FTI-277 HCl Chemical Structure

CAS NO. 180977-34-8

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
25 mg
$300.00
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Biological Activity

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
Targets
FTase GGTase I
500 pM50 nM
In vitro DMSO 90 mg/mL (185.92 mM)
Water 16 mg/mL (33.04 mM)
Ethanol Warmed: 13 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.66 mL 103.29 mL 206.58 mL
0.5 mM 4.13 mL 20.66 mL 41.32 mL
1 mM 2.07 mL 10.33 mL 20.66 mL
5 mM 0.41 mL 2.07 mL 4.13 mL

*The above data is based on the productmolecular weight 484.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14439
Actions Inhibitor
CAS No. 180977-34-8
Formula C22H30ClN3O3S2
M. Wt 484.07
Purity >98%
Synonyms FTI 277, FTI277
SMILES COC(=O)[[email protected]](CCSC)NC(=O)C1=C(C=C(C=C1)NC[[email protected]](CS)N)C2=CC=CC=C2.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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