FTI 277

Catalog No.: A12368

FTase inhibitor

FTI 277

FTI 277 Chemical Structure

CAS NO. 170006-73-2

FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
25 mg
$300.00
50 mg
$500.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.8 mL 89.02 mL 178.05 mL
0.5 mM 3.56 mL 17.8 mL 35.61 mL
1 mM 1.78 mL 8.9 mL 17.8 mL
5 mM 0.36 mL 1.78 mL 3.56 mL

*The above data is based on the productmolecular weight 561.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A12368
Actions Inhibitor
M. Wt 561.64
Formula C22H29N3O3S2.C2HF3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 170006-73-2
Synonyms FTI-277,FTI277
SMILES CSCC[[email protected]](NC(=O)C1CCC(NC[[email protected]@H](N)CS)CC1C1CCCCC1)C(=O)OC.OC(=O)C(F)(F)F

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