FTI 277

Catalog No.: A12368

FTase inhibitor

FTI 277

FTI 277 Chemical Structure

CAS NO. 170006-73-2, 1217447-06-7

FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
25 mg
$300.00
50 mg
$500.00
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Biological Activity

FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.8 mL 89.02 mL 178.05 mL
0.5 mM 3.56 mL 17.8 mL 35.61 mL
1 mM 1.78 mL 8.9 mL 17.8 mL
5 mM 0.36 mL 1.78 mL 3.56 mL

*The above data is based on the productmolecular weight 561.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12368
Actions Inhibitor
CAS No. 170006-73-2, 1217447-06-7
Formula C22H29N3O3S2.C2HF3O2
M. Wt 561.64
Purity >98%
Synonyms FTI-277,FTI277, FTI-277 trifluoroacetate
SMILES COC(=O)[[email protected]](CCSC)NC(=O)C1=C(C=C(C=C1)NC[[email protected]](CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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