Furamidine is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1), exhibiting an IC50 of 9.4 μM, while maintaining a considerably lower affinity for PRMT5, PRMT6, and PRMT4. Additionally, Furamidine acts as a reversible, competitive inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP-1), demonstrating enhanced inhibition with duplex DNA substrates. This compound has applications in research focusing on methylation patterns and DNA repair mechanisms, as well as serving as an antiparasitic agent.
Furamidine is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1), exhibiting an IC50 of 9.4 μM, while maintaining a considerably lower affinity for PRMT5, PRMT6, and PRMT4. Additionally, Furamidine acts as a reversible, competitive inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP-1), demonstrating enhanced inhibition with duplex DNA substrates. This compound has applications in research focusing on methylation patterns and DNA repair mechanisms, as well as serving as an antiparasitic agent.
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