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Biological Activity
G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA. It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.05 mL | 115.23 mL | 230.45 mL |
| 0.5 mM | 4.61 mL | 23.05 mL | 46.09 mL |
| 1 mM | 2.3 mL | 11.52 mL | 23.05 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.61 mL |
*The above data is based on the productmolecular weight 433.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18540 |
|---|---|
| Actions | Antagonist |
| CAS No. | 2244035-16-1 |
| Formula | C26H24ClNO3 |
| M. Wt | 433.93 |
| Purity | >98% |
| Synonyms | G-907, G 907 |
| SMILES | O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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