GABAA receptor agent 2 TFA is a potent GABAA receptor antagonist that exhibits an IC50 of 24 nM in human α1β2γ2 GABAA-expressing tsA201 cells and a Ki of 28 nM in rat GABAA receptors. This compound selectively inhibits GABAA receptor activity without affecting four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3). It serves as a valuable tool for studying GABAA receptor-mediated pathways and exploring therapeutic interventions in neurological disorders.
GABAA receptor agent 2 TFA is a potent GABAA receptor antagonist that exhibits an IC50 of 24 nM in human α1β2γ2 GABAA-expressing tsA201 cells and a Ki of 28 nM in rat GABAA receptors. This compound selectively inhibits GABAA receptor activity without affecting four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3). It serves as a valuable tool for studying GABAA receptor-mediated pathways and exploring therapeutic interventions in neurological disorders.
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