GABAA receptor modulator-5 is a selective modulator of the GABA A receptor, demonstrating EC50 values of 56 nM and 10 nM for the α1β2γ2 and α4β3δ subtypes, respectively. This compound exhibits favorable pharmacokinetic properties in rat models and shows a threshold dose of 23.3 μmol/kg for loss of rollover reflex (LORR), indicating slight toxicity. GABAA receptor modulator-5 has potential applications in the research of postpartum depression and may contribute to therapeutic strategies targeting GABAergic pathways.
GABAA receptor modulator-5 is a selective modulator of the GABA A receptor, demonstrating EC50 values of 56 nM and 10 nM for the α1β2γ2 and α4β3δ subtypes, respectively. This compound exhibits favorable pharmacokinetic properties in rat models and shows a threshold dose of 23.3 μmol/kg for loss of rollover reflex (LORR), indicating slight toxicity. GABAA receptor modulator-5 has potential applications in the research of postpartum depression and may contribute to therapeutic strategies targeting GABAergic pathways.
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