Fig. 1 · Structure
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Gallamine
Muscarinic M2 Acetylcholine Receptor Antagonist
Gallamine is a selective allosteric antagonist of the muscarinic M2 acetylcholine receptor, exhibiting an EC50 value of 130 nM in promoting the dissociation of [3H]NMS from porcine muscarinic M2 receptors. Additionally, it serves as an acetylcholinesterase inhibitor with varying IC50 values against different isoforms: 1070 μM for EeAChE, 1480 μM for hAChE, and 235 μM for hBChE. Gallamine is known to elevate levels of free norepinephrine and is utilized in research exploring muscle relaxation and pharmacological modulation of cholinergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 153-76-4 |
| Applications | Muscarinic M2 Acetylcholine Receptor Antagonist |
| Formula | C24H45N3O3 |
| Molecular Weight | 423.63 |
| SMILES | CCN(CC)CCOC1=C(OCCN(CC)CC)C(OCCN(CC)CC)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.