GAT229 is a positive allosteric modulator of the CB1 receptor, demonstrating significant potential in the reduction of intraocular pressure (IOP). Research indicates that GAT229 effectively enhances CB1 receptor-mediated IOP-lowering effects in high IOP mouse models. A solution of 0.2% GAT229 or administration at a dosage of 10 mg/kg results in notable IOP reduction, making it a valuable tool for studies focused on glaucoma and related conditions associated with elevated intraocular pressure.
GAT229 is a positive allosteric modulator of the CB1 receptor, demonstrating significant potential in the reduction of intraocular pressure (IOP). Research indicates that GAT229 effectively enhances CB1 receptor-mediated IOP-lowering effects in high IOP mouse models. A solution of 0.2% GAT229 or administration at a dosage of 10 mg/kg results in notable IOP reduction, making it a valuable tool for studies focused on glaucoma and related conditions associated with elevated intraocular pressure.
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