GAT564 is a potent allosteric modulator of the cannabinoid 1 receptor (CB1R), exhibiting EC50 values of 87 nM for cAMP and 320 nM for β-arrestin2. This compound enhances orthosteric ligand binding to hCB1R, indicating its role in modulating receptor activity. In research applications, GAT564 demonstrates significant efficacy as a topical agent, effectively reducing intraocular pressure (IOP) in ocular normotensive murine models of glaucoma.
GAT564 is a potent allosteric modulator of the cannabinoid 1 receptor (CB1R), exhibiting EC50 values of 87 nM for cAMP and 320 nM for β-arrestin2. This compound enhances orthosteric ligand binding to hCB1R, indicating its role in modulating receptor activity. In research applications, GAT564 demonstrates significant efficacy as a topical agent, effectively reducing intraocular pressure (IOP) in ocular normotensive murine models of glaucoma.
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