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- Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
- Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
- Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536
Biological Activity
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
| In vitro (25°C) | DMSO | 72 mg/mL (170.9 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O | 11.8 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.74 mL | 118.68 mL | 237.36 mL |
| 0.5 mM | 4.75 mL | 23.74 mL | 47.47 mL |
| 1 mM | 2.37 mL | 11.87 mL | 23.74 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.75 mL |
*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10258 |
|---|---|
| Actions | Antagonist |
| CAS No. | 879085-55-9 |
| Formula | C19H14Cl2N2O3S |
| M. Wt | 421.3 |
| Purity | >98% |
| SMILES | ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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