GDC-0449 (Vismodegib)
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Discription | GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. |
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Catalog Num | A10258 |
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Formula | C19H14Cl2N2O3S |
Molecular Weight | 421.3 |
CAS Number | 879085-55-9 |
SMILES | ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 72 mg/mL (170.9 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O | 11.8 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 23.74 mL | 118.68 mL | 237.36 mL |
0.5 mM | 4.75 mL | 23.74 mL | 47.47 mL |
1 mM | 2.37 mL | 11.87 mL | 23.74 mL |
5 mM | 0.47 mL | 2.37 mL | 4.75 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2