GDC-0449 (Vismodegib)

Catalog No.: A10258

Hedgehog antagonist

GDC-0449 (Vismodegib)

GDC-0449 (Vismodegib) Chemical Structure

CAS NO. 879085-55-9

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

Availability: In stock

Package Price Qty
25 mg

Regular Price: $50.00

Special Price $40.00

50 mg

Regular Price: $60.00

Special Price $48.00

200 mg

Regular Price: $110.00

Special Price $88.00

10mM * 1mL in DMSO
$50.00
Warning WARNING: Attention California Residents: This product can expose you to chemicals including Adriamycin, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
In vitro (25°C) DMSO 84 mg/mL (199.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.74 mL 118.68 mL 237.36 mL
0.5 mM 4.75 mL 23.74 mL 47.47 mL
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10258
Actions Antagonist
M. Wt 421.3
Formula C19H14Cl2N2O3S
Solubility DMSO>84mg/mL Water<1mg/mL Ethanol>10mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 879085-55-9
Synonyms N/A
SMILES ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3

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