GDC-0449 (Vismodegib)

Catalog No.: A10258
Hedgehog antagonist
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
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GDC-0449 50mg
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GDC-0449 200mg
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GDC-0449 25mg
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GDC-0449 (Vismodegib) 10mM * 1mL in DMSO
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Important Notice: For research use only. We do not sell to patients.

Prop65 Warning  WARNING: Attention California Residents: This product can expose you to chemicals including GDC-0449 (Vismodegib) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to

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Adooq Products cited in reputable paper
Adooq's GDC-0449 (Vismodegib) has been cited by 5 publications
  • Yan Guo, .et al. , Differentiation, 2023, May-Jun;131:82-88 PMID: 37178555
  • Mucahit Varli, .et al. , Sci Rep, 2023, Feb 16;13(1):2811 PMID: 36797277
  • Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
  • Yi Yang, .et al. , Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
  • Olesen UH, .et al. , Lasers Surg Med, 2018, Aug 28 PMID: 30152536
  • Biological Activity
    Discription GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
    Product Information
    Catalog Num A10258
    Formula C19H14Cl2N2O3S
    Molecular Weight 421.3
    CAS Number 879085-55-9
    SMILES ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 72 mg/mL (170.9 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O 11.8 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.74 mL 118.68 mL 237.36 mL
    0.5 mM 4.75 mL 23.74 mL 47.47 mL
    1 mM 2.37 mL 11.87 mL 23.74 mL
    5 mM 0.47 mL 2.37 mL 4.75 mL
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