GDC-0449 (Vismodegib)

Catalog No.: A10258

Hedgehog antagonist

GDC-0449 (Vismodegib)

GDC-0449 (Vismodegib) Chemical Structure

CAS NO. 879085-55-9

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

Availability: In stock

Package Price Qty
25 mg
50 mg
200 mg
10mM * 1mL in DMSO
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning WARNING: Attention California Residents: This product can expose you to chemicals including GDC-0449 (Vismodegib) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
  • Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536

Biological Activity

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
In vitro (25°C) DMSO 84 mg/mL (199.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.74 mL 118.68 mL 237.36 mL
0.5 mM 4.75 mL 23.74 mL 47.47 mL
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10258
Actions Antagonist
M. Wt 421.3
Formula C19H14Cl2N2O3S
Solubility DMSO>84mg/mL Water<1mg/mL Ethanol>10mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 879085-55-9
SMILES ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy GDC-0449 (Vismodegib) | GDC-0449 (Vismodegib) Supplier | purchase | cost | manufacturer | order | distributor | buy 879085-55-9| 879085-55-9 Supplier | purchase 879085-55-9 | 879085-55-9 cost | 879085-55-9 manufacturer | order 879085-55-9 | 879085-55-9 distributor