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GDC-0449 (Vismodegib)

Catalog No.: A10258

Hedgehog antagonist

GDC-0449 (Vismodegib)

GDC-0449 (Vismodegib) Chemical Structure

CAS NO. 879085-55-9

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

Availability: In stock

Package Price Qty
25 mg
50 mg
200 mg
10mM * 1mL in DMSO
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including GDC-0449 (Vismodegib) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
  • Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
  • Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536

Biological Activity

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
In vitro (25°C) DMSO 72 mg/mL (170.9 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O 11.8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.74 mL 118.68 mL 237.36 mL
0.5 mM 4.75 mL 23.74 mL 47.47 mL
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10258
Actions Antagonist
CAS No. 879085-55-9
Formula C19H14Cl2N2O3S
M. Wt 421.3
Purity >98%
SMILES ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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