GDC-0973 (Cobimetinib)

Catalog No.: A11441

MEK1 inhibitor

GDC-0973 (Cobimetinib)

GDC-0973 (Cobimetinib) Chemical Structure

CAS NO. 934660-93-2

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.

Availability: In stock

Package Price Qty
5 mg
$85.00
10 mg
$110.00
25 mg
$200.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

Biological Activity

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
Targets
MEK1
4.2 nM
In vitro (25°C) DMSO 88 mg/mL (165.62 mM)
Water Insoluble
Ethanol Warmed: 41 mg/mL (77.17 mM)
In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.86 mL 94.32 mL 188.64 mL
0.5 mM 3.77 mL 18.86 mL 37.73 mL
1 mM 1.89 mL 9.43 mL 18.86 mL
5 mM 0.38 mL 1.89 mL 3.77 mL

*The above data is based on the productmolecular weight 530.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11441
Actions Inhibitor
CAS No. 934660-93-2
Formula C21H21F3IN3O2
M. Wt 530.1
Purity >98%
Synonyms XL518, XL 518, XL-518, RG7420
SMILES C1CCN[[email protected]@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy GDC-0973 (Cobimetinib) | GDC-0973 (Cobimetinib) Supplier | purchase | cost | manufacturer | order | distributor | buy 934660-93-2| 934660-93-2 Supplier | purchase 934660-93-2 | 934660-93-2 cost | 934660-93-2 manufacturer | order 934660-93-2 | 934660-93-2 distributor
Rewards