Signaling Pathway
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| Discription | Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. | ||
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| Catalog Num | A11441 |
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| Formula | C21H21F3IN3O2 |
| Molecular Weight | 530.1 |
| CAS Number | 934660-93-2 |
| SMILES | C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O |
| Synonyms | XL518, XL 518, XL-518, RG7420 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 88 mg/mL (165.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 41 mg/mL (77.17 mM) | ||
| In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.86 mL | 94.32 mL | 188.64 mL |
| 0.5 mM | 3.77 mL | 18.86 mL | 37.73 mL |
| 1 mM | 1.89 mL | 9.43 mL | 18.86 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
