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GDC-0973 (Cobimetinib)

GDC-0973 (Cobimetinib)

Name: GDC-0973 (Cobimetinib)
Brand: Adooq Bioscience
SKU: A11441
Rating: 100 (1 reviews)

Catalog No.: A11441

MEK1 inhibitor

Product Citations (1)

GDC-0973 (Cobimetinib) Chemical Structure

CAS NO. 934660-93-2

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.

Availability: In stock

Package	Price	Qty
5 mg	$85.00
10 mg	$110.00
25 mg	$200.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq GDC-0973 (Cobimetinib)

Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

Biological Activity

Targets

MEK1
4.2 nM

Solubility *

In vitro (25°C)	DMSO	88 mg/mL (165.62 mM)
	Water	Insoluble
	Ethanol	Warmed: 41 mg/mL (77.17 mM)
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.86 mL	94.32 mL	188.64 mL
0.5 mM	3.77 mL	18.86 mL	37.73 mL
1 mM	1.89 mL	9.43 mL	18.86 mL
5 mM	0.38 mL	1.89 mL	3.77 mL

*The above data is based on the productmolecular weight 530.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11441
Actions	Inhibitor
CAS No.	934660-93-2
Formula	C21H21F3IN3O2
M. Wt	530.1
Purity	>98%
Synonyms	XL518, XL 518, XL-518, RG7420
SMILES	C1CCN[[email protected]@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.