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Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
Targets
| MEK1 | ||||
| 4.2 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.86 mL | 94.32 mL | 188.64 mL |
| 0.5 mM | 3.77 mL | 18.86 mL | 37.73 mL |
| 1 mM | 1.89 mL | 9.43 mL | 18.86 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
*The above data is based on the productmolecular weight 530.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11441 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 530.1 |
| Formula | C21H21F3IN3O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 934660-93-2 |
| Synonyms | XL518, XL 518, XL-518, RG7420 |
| SMILES | C1CCN[[email protected]@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O |
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