GDC-0973 (Cobimetinib)

Catalog No.: A11441

MEK1 inhibitor

GDC-0973 (Cobimetinib)

GDC-0973 (Cobimetinib) Chemical Structure

CAS NO. 934660-93-2

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.

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Package Price Qty
5 mg
$85.00
10 mg
$110.00
25 mg
$200.00
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  • Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

Biological Activity

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
Targets
MEK1
4.2 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.86 mL 94.32 mL 188.64 mL
0.5 mM 3.77 mL 18.86 mL 37.73 mL
1 mM 1.89 mL 9.43 mL 18.86 mL
5 mM 0.38 mL 1.89 mL 3.77 mL

*The above data is based on the productmolecular weight 530.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11441
Actions Inhibitor
M. Wt 530.1
Formula C21H21F3IN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 934660-93-2
Synonyms XL518, XL 518, XL-518, RG7420
SMILES C1CCN[[email protected]@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O

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