GDC-0980 (Apitolisib, RG7422)

Catalog No.: A11023

mTOR/PI3K Inhibitor

GDC-0980 (Apitolisib, RG7422)

GDC-0980 (Apitolisib, RG7422) Chemical Structure

CAS NO. 1032754-93-0

GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $100.00

Special Price $80.00

50 mg

Regular Price: $350.00

Special Price $280.00

100 mg

Regular Price: $580.00

Special Price $464.00

10mM * 1mL in DMSO
$119.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.
Targets
p110α (Cell-free assay) p110δ (Cell-free assay) p110γ (Cell-free assay) mTOR (Cell-free assay) p110β (Cell-free assay)
5 nM7 nM14 nM17 nM(Ki app)27 nM
In vitro (25°C) DMSO 20 mg/mL (40.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.06 mL 100.28 mL 200.56 mL
0.5 mM 4.01 mL 20.06 mL 40.11 mL
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL

*The above data is based on the productmolecular weight 498.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11023
Actions Inhibitor
M. Wt 498.6
Formula C23H30N8O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1032754-93-0
Synonyms GDC0980
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[[email protected]](C)O

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