GDC-2992 is an orally bioavailable PROTAC degrader targeting the androgen receptor (AR). With a DC50 of 2.7 nM for AR degradation and an IC50 of 9.7 nM for inhibiting cell proliferation in VCaP cells, GDC-2992 serves as a valuable tool in prostate cancer research. This compound facilitates investigations into the therapeutic potential of targeted protein degradation in androgen receptor-mediated signaling pathways.
GDC-2992 is an orally bioavailable PROTAC degrader targeting the androgen receptor (AR). With a DC50 of 2.7 nM for AR degradation and an IC50 of 9.7 nM for inhibiting cell proliferation in VCaP cells, GDC-2992 serves as a valuable tool in prostate cancer research. This compound facilitates investigations into the therapeutic potential of targeted protein degradation in androgen receptor-mediated signaling pathways.
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