Gefapixant citrate is a potent antagonist of the purinergic P2X3 receptor, exhibiting IC50 values of approximately 30 nM against recombinant human P2X3 homotrimers and 100-250 nM at human P2X2/3 heterotrimeric receptors. This compound is valuable for research related to chronic cough and knee osteoarthritis, providing insights into the modulation of nociceptive signaling pathways associated with these conditions. Its oral bioavailability further enhances its applicability in in vivo studies.
Gefapixant citrate is a potent antagonist of the purinergic P2X3 receptor, exhibiting IC50 values of approximately 30 nM against recombinant human P2X3 homotrimers and 100-250 nM at human P2X2/3 heterotrimeric receptors. This compound is valuable for research related to chronic cough and knee osteoarthritis, providing insights into the modulation of nociceptive signaling pathways associated with these conditions. Its oral bioavailability further enhances its applicability in in vivo studies.
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