Gefitinib-d3 is a deuterium-labeled derivative of Gefitinib, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits robust antitumor activity by inhibiting EGF-stimulated growth in tumor cells with an IC50 of 54 nM and effectively blocking EGF-induced EGFR autophosphorylation. This stable isotope variant is particularly valuable for research applications involving drug metabolism and pharmacokinetics, as well as studying the mechanisms of autophagy associated with EGFR signaling.
Gefitinib-d3 is a deuterium-labeled derivative of Gefitinib, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits robust antitumor activity by inhibiting EGF-stimulated growth in tumor cells with an IC50 of 54 nM and effectively blocking EGF-induced EGFR autophosphorylation. This stable isotope variant is particularly valuable for research applications involving drug metabolism and pharmacokinetics, as well as studying the mechanisms of autophagy associated with EGFR signaling.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
