Gefitinib-d6 is the deuterated form of Gefitinib, a highly selective and orally bioavailable inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 33 nM. This compound effectively inhibits EGF-mediated tumor cell proliferation (IC50 of 54 nM) and prevents EGFR autophosphorylation in cancer cells. Additionally, Gefitinib can induce autophagy, further contributing to its antitumoral effects. Gefitinib-d6 is valuable for studies involving metabolic labeling and pharmacokinetics in cancer research.
Gefitinib-d6 is the deuterated form of Gefitinib, a highly selective and orally bioavailable inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 33 nM. This compound effectively inhibits EGF-mediated tumor cell proliferation (IC50 of 54 nM) and prevents EGFR autophosphorylation in cancer cells. Additionally, Gefitinib can induce autophagy, further contributing to its antitumoral effects. Gefitinib-d6 is valuable for studies involving metabolic labeling and pharmacokinetics in cancer research.
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