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GF 109203X

Catalog No.: A13197

PKC inhibitor

GF 109203X

GF 109203X Chemical Structure

CAS NO. 133052-90-1

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).

Availability: In stock

Package Price Qty
10 mg
$120.00
25 mg
$240.00
50 mg
$450.00
100 mg
$850.00
10mM * 1mL in DMSO
$100.00
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Biological Activity

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
Targets
Target Value
PKCβ2IC50: 16nM
PKCβ1IC50: 17nM
PKCαIC50: 20nM
PKCγIC50: 20nM
PDGFRIC50: 65μM
EGFRIC50: >100μM
Insulin ReceptorIC50: >100μM
In vitro DMSO 70 mg/mL (169.7 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.22 mL 242.43 mL
0.5 mM 4.85 mL 24.24 mL 48.49 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13197
Actions Inhibitor
CAS No. 133052-90-1
Formula C25H24N4O2
M. Wt 412.49
Purity >98%
Synonyms GF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
SMILES CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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