GF 109203X

Catalog No.: A13197

PKC inhibitor

GF 109203X Chemical Structure

CAS NO. 133052-90-1

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $120.00

Special Price $96.00

25 mg

Regular Price: $240.00

Special Price $192.00

50 mg

Regular Price: $450.00

Special Price $360.00

100 mg

Regular Price: $850.00

Special Price $680.00

10mM * 1mL in DMSO
$100.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
Targets
Target Value
PKCβ2IC50: 16nM
PKCβ1IC50: 17nM
PKCαIC50: 20nM
PKCγIC50: 20nM
PDGFRIC50: 65μM
EGFRIC50: >100μM
Insulin ReceptorIC50: >100μM
In vitro DMSO 82 mg/mL (198.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.22 mL 242.43 mL
0.5 mM 4.85 mL 24.24 mL 48.49 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13197
Actions Inhibitor
M. Wt 412.49
Formula C25H24N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133052-90-1
Synonyms GF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
SMILES CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy GF 109203X | GF 109203X Supplier | purchase GF 109203X | GF 109203X cost | GF 109203X manufacturer | order GF 109203X | GF 109203X distributor | buy 133052-90-1| 133052-90-1 Supplier | purchase 133052-90-1 | 133052-90-1 cost | 133052-90-1 manufacturer | order 133052-90-1 | 133052-90-1 distributor
Rewards