GF 15 is a centrosomal clustering inhibitor that acts by inducing multipolar spindles with an EC50 value of 900 nM. As a derivative of griseofulvin, it effectively inhibits tubulin polymerization at concentrations exceeding 25 μM. GF 15 demonstrates notable antitumor activity, significantly inhibiting tumor growth and improving survival rates in mouse xenograft models of human colon cancer and multiple myeloma. This reagent is valuable for researchers studying cellular mitosis and the mechanisms of cancer progression.
GF 15 is a centrosomal clustering inhibitor that acts by inducing multipolar spindles with an EC50 value of 900 nM. As a derivative of griseofulvin, it effectively inhibits tubulin polymerization at concentrations exceeding 25 μM. GF 15 demonstrates notable antitumor activity, significantly inhibiting tumor growth and improving survival rates in mouse xenograft models of human colon cancer and multiple myeloma. This reagent is valuable for researchers studying cellular mitosis and the mechanisms of cancer progression.
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