GKT136901 hydrochloride is a highly selective and orally active inhibitor of NADPH oxidase isozymes NOX1 and NOX4, exhibiting inhibition constants of 160 nM and 165 nM, respectively. This compound also functions as a direct scavenger of peroxynitrite, enhancing its therapeutic potential. GKT136901 hydrochloride is primarily utilized in research settings focusing on diabetic nephropathy, stroke, and neurodegenerative diseases, while also demonstrating notable anti-inflammatory properties.
GKT136901 hydrochloride is a highly selective and orally active inhibitor of NADPH oxidase isozymes NOX1 and NOX4, exhibiting inhibition constants of 160 nM and 165 nM, respectively. This compound also functions as a direct scavenger of peroxynitrite, enhancing its therapeutic potential. GKT136901 hydrochloride is primarily utilized in research settings focusing on diabetic nephropathy, stroke, and neurodegenerative diseases, while also demonstrating notable anti-inflammatory properties.
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