GKT136901 is a selective and orally active inhibitor of NADPH oxidases NOX1 and NOX4, exhibiting inhibition constants (Kis) of 160 nM and 165 nM, respectively. This compound also serves as a direct scavenger of peroxynitrite, contributing to its anti-inflammatory properties. GKT136901 is particularly useful in research focused on diabetic nephropathy, stroke, and neurodegenerative diseases, providing valuable insights into oxidative stress-related pathologies.
GKT136901 is a selective and orally active inhibitor of NADPH oxidases NOX1 and NOX4, exhibiting inhibition constants (Kis) of 160 nM and 165 nM, respectively. This compound also serves as a direct scavenger of peroxynitrite, contributing to its anti-inflammatory properties. GKT136901 is particularly useful in research focused on diabetic nephropathy, stroke, and neurodegenerative diseases, providing valuable insights into oxidative stress-related pathologies.
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