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GLPG-3221

Catalog No.: A66483
CFTR Corrector
GLPG-3221 is a potent, orally active corrector of cystic fibrosis transmembrane conductance regulator (CFTR), exhibiting an EC50 value of 105 nM. This compound plays a crucial role in restoring CFTR function, making it significant for the treatment of cystic fibrosis. Its primary application lies in research focused on therapies aimed at enhancing CFTR activity and improving chloride transport in epithelial cells.
GLPG-3221 2222264-64-2 CFTR Corrector
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGLPG-3221 is a potent, orally active corrector of cystic fibrosis transmembrane conductance regulator (CFTR), exhibiting an EC50 value of 105 nM. This compound plays a crucial role in restoring CFTR function, making it significant for the treatment of cystic fibrosis. Its primary application lies in research focused on therapies aimed at enhancing CFTR activity and improving chloride transport in epithelial cells.
Product Information
Catalog NumA66483
FormulaC30H37F3N2O6
Molecular Weight578.62
CAS Number2222264-64-2
SMILESO=C(O)[C@H]1N(C([C@@H]2CCCCO2)=O)[C@@H](C3=CC=CC=C3C)[C@@H](OCC4=CC(C(F)(F)F)=CN=C4OC)[C@@H]1C(C)(C)C
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Membrane Transporters-Ion Channels > CFTR